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Modality 03

Nanobodies (Fab, scFv, VHH)

Compact antibody fragments enabling deeper tissue penetration, modular assembly, and efficient microbial expression for next-generation biologics.

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Fab — Fragment Antigen-Binding structure
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scFv — Single-Chain Variable Fragment structure
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VHH nanobody structure

Overview

Engineering small formats with outsized impact.

We design Fab, scFv, and VHH (single-domain) molecules with tuned affinity, thermostability, and humanization profiles — ideal building blocks for multi-specifics, ADCs, and imaging agents.

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Computational design and optimization of Fab
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Computational design and optimization of scFv
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Computational design and optimization of VHH nanobody