[ Insight ]
Antibody Characterization by Liquid Chromatography and Mass Spectrometry (LC-MS/MS)
Comprehensive LC-MS/MS workflows — intact mass, subunit mass, peptide mapping, glycosylation, and sequence variant analysis — for antibody quality control, developability assessment, and production optimization.
2026
[ Insight ]
Triaging Diverse Antibody Candidates
Triaging diverse antibody candidates enables efficient triage of antibody therapeutics against a target of interest using both in vitro and in silico properties to prioritize the best candidates and reduce bench workload.
2026
[ Insight ]
Why Early Antibody Developability Assessment Matters?
Discover why early antibody developability assessment is critical for identifying liabilities, reducing development risk, improving candidate selection, and accelerating therapeutic success.
2026
[ Technical Note ]
Computational Approaches to Antibody Humanization
An overview of in silico frameworks for CDR grafting and sequence optimization — humanization strategies, structural considerations (CSRs, Vernier zone, CDR stem residues), framework ranking, and germline-library scoring.
2026
[ Technical Note ]
H3 Loop Modeling for VHH, scFv, and Fab Formats
Refinement strategies, accuracy benchmarks, and tooling guidance for the most variable CDR region.
2024
[ Case Study ]
In Silico Residue Scanning Guides Affinity Maturation
Using Schrödinger BioLuminate to systematically scan interface residues and identify tunable positions for affinity improvement.
2026
[ Case Study ]
From Aggregation Hotspot Prediction to Risk Mitigation: Improving MEDI-1912 Developability
Structure-guided aggregation risk mitigation using Schrödinger BioLuminate to improve antibody developability and reduce aggregation propensity.
2026
[ Case Study ]
AI-Driven Mapping of the HER2-Herceptin Antibody-Antigen Interface
Using AI-driven structural modeling, we mapped the HER2-Herceptin antibody-antigen interface to identify critical binding determinants and accelerate data-driven antibody development.
2026
[ Case Study ]
High-Throughput Antibody Expression Optimization
A scalable workflow for rapidly screening, expressing, and selecting high-quality antibody candidates for downstream development.
2026