01
Antibody Sequence Design & Optimization
- Epitope-guided antibody design
- Sequence engineering for affinity, stability, and specificity
- Humanization and mutation strategies
- CDR grafting and framework optimization
Services
Integrated Discovery & Development Services
01 — Core Capabilities
Antibody design, Assessment & Maturation
02
In-Silico Developability Assessment
- Aggregation hotspot prediction
- Stability and solubility prediction
- Immunogenicity risk scoring
- Early developability triaging of antibody panels
03
Antibody Structural Modeling & Refinement
- Antibody structure prediction (Fab, scFv, VHH, bispecifics)
- Antibody structure quality assessment
- CDR loop modeling (H3 loop refinement)
04
Antibody-Antigen Docking & Interface Analysis
- Docking antibody-antigen complexes
- Interface hotspot identification
- Alanine scanning for affinity-driving residues
- Residue scanning and epitope/paratope prediction
05
In-Silico Affinity Maturation
- Computational affinity improvement
- Mutational scanning to identify beneficial substitutions
- Ranking variants based on predicted affinity and developability
06
Computational Screening & Candidate Ranking
- Multiparameter optimization (MPO) scoring
- Ranking candidates based on in-silico and in-vitro data
- Generating LiveReports for clients
02 — Packages
Developability & Process Optimization
Package A
Cell Line Development & Process Development
- Cell line construction
- Cell line characterization
- Selection of the optimal CHO or HEK host cells system and vector construction
- Process optimization
- Scale-up strategy
Package B
Transient & Stable Antibodies/Proteins Production
- Transient expression
- Stable cell line production
- Small scale to large scale production
- Purification development and optimization
- High yield & high quality expression
Package C
Biological Activity Assay Development
- Assay strategy & development
- Binding & functional assays
- Assay validation
- Fit-for-purpose solutions
Package D
Analytical Characterization
- Physicochemical analysis
- Purity & impurity profiling
- Structural characterization
- Aggregation & stability analysis
- Method development & validation
03 — Characterization
Bioanalytical Capabilities
01
Binding (SPR/BLI)
Surface Plasmon Resonance (SPR) and Bio-Layer Interferometry (BLI) for analyzing biomolecular interactions and binding kinetics.
02
Aggregation (aSEC/DLS)
Analytical Size-Exclusion Chromatography (aSEC) and Dynamic Light Scattering (DLS) to characterize protein aggregation and particle size.
03
Expression (Expi293/ExpiCHO)
High-yield transient protein expression using Expi293 and ExpiCHO mammalian expression systems.
04
Wet-lab Antibody Characterization (LC/MS)
Intact mass analysis, subunit analysis, peptide mapping, and glycosylation analysis via LC/MS for comprehensive antibody profiling.
05
Thermal Stability (DSC/DSF)
Differential Scanning Calorimetry (DSC) and Differential Scanning Fluorimetry (DSF) to assess protein thermal stability and unfolding.